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If DRd, DKd, KRd, or IKd in 1L RRMM BTZ refractory patients, which Tx in 2L+? 

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If DRd, DKd, KRd, or IKd in 1L RRMM BTZ refractory patients, which Tx in 2L+?

If needed ; - ):

If daratumumab+lenalidomide+dexamethasone, daratumumab+carfilzomib+dexamethasone, carfilzomib+lenalidomide+dexamethasose, or isatuximab+carfilzomib+dexamethasone is used in the frontline relapse/refractory multiple myeloma setting in bortezomib-refractory patients, what will be the treatment in the second and subsequent lines?